Out of nowhere, suburban housewife Mary Alice Young takes her own life, then narrates the events that follow for us. The focus is on her four friends theres manhungry single mother Susan Mayer, excareer woman and now mother of four Lynette Scarvo, Martha Stewartonsteroids Bree Van De Kamp, and Gabrielle Solis, who has everything shes ever wanted but still cant find happiness. From her heavenly perch, Mary Alice sees all and offers her own twisted take on the weekly goingson.